Isradipine

A to Z Drug Facts

Isradipine

	Action
	Indications
	Contraindications
	Route/Dosage
	Interactions
	Lab Test Interferences
	Adverse Reactions
	Precautions
Patient Care Considerations
	Administration/Storage
	Assessment/Interventions
	Patient/Family Education

(iss-RAHD-ih-peen)

DynaCirc, DynaCirc CR

Class: Calcium channel blocker

Action Reduces systemic vascular resistance and BP by inhibiting movement of calcium ions across cell membrane in systemic and coronary vascular smooth muscle and myocardium.

Indications Treatment of hypertension.

Contraindications Standard considerations.

Route/Dosage

ADULTS: PO 2.5 to 10 mg/day in 2 divided doses (max dose 20 mg/day).

Interactions None well documented.

Lab Test Interferences None well documented.

Adverse Reactions

CV: Peripheral edema; flushing; palpitations; angina; tachycardia; hypotension; syncope; CHF; MI; atrial or ventricular fibrillation. CNS: Dizziness; lightheadedness; headache; fatigue; lethargy; weakness; shakiness; psychiatric disturbances. DERM: Rash. GI: Nausea; diarrhea; constipation; abdominal discomfort; cramps; dyspepsia; vomiting. GU: Urinary frequency; micturition disorders; sexual difficulties. RESP: Shortness of breath; dyspnea; wheezing. OTHER: Transient ischemic attack; stroke.

Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. CHF: Use with caution in patients with CHF.

PATIENT CARE CONSIDERATIONS

Administration/Storage

May administer with or without food.
Store in tightly closed container at room temperature. Protect from light.

Assessment/Interventions

Obtain patient history, including drug history and any known allergies. Note cardiovascular disease.
Monitor BP, cardiac and respiratory function during therapy.
Monitor for dizziness, headache, and peripheral edema.
Assist patient with ambulation if dizziness occurs.

OVERDOSAGE: SIGNS & SYMPTOMS
	Hypotension, dizziness, slurred speech, nausea, weakness, drowsiness, confusion

Patient/Family Education

Explain that dosage will be tapered slowly before stopping to avoid withdrawal symptoms. Warn patient that sudden discontinuation may cause serious chest pain.
Tell patient to brush and floss teeth regularly to minimize gum changes (eg, overgrowth of gums).
Instruct patient to report the following symptoms to physician: Irregular heart beat, shortness of breath, swelling of hands or feet, pronounced dizziness, constipation, nausea, or hypotension.
Advise patient that drug may cause dizziness and to use caution while driving or performing other tasks requiring mental alertness.